Apple Fruit Copper Amine Oxidase Isoforms: Peroxisomal MdAO1 Prefers Diamines as Substrates, Whereas Extracellular MdAO2 Exclusively Utilizes Monoamines
نویسندگان
چکیده
منابع مشابه
Structural studies of copper amine oxidase
Introduction Copper amine oxidases are ubiquitous metalloenzymes. Their function in prokaryotes and lower eukaryotes is to utilise amines as a source for carbon and nitrogen. In higher eukaryotes, their roles are less well understood, but have been linked with cell signalling, growth and development, and cell death. Despite this apparent diversity, their fundamental role is to catalyse the oxid...
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The activity of highly purified bovine aortic lysyl oxidase against an insoluble aortic elastin substrate is inhibited by lysine, nonpeptidyl derivatives of lysine, P-aminopropionitrile (BAPN), and aliphatic monoand diamines. Inhibition requires the presence of a primary amino function. Although other stereochemical requirements for inhibition are not unusually rigid, inhibition is sensitive to...
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The process by which molecular oxygen is activated to enable it to function as an electron acceptor in biology is poorly understood. The quinoprotein copper-containing amine oxidase (CuAO) catalyses the conversion of primary amines into aldehydes. As well as copper, the enzyme contains an organic cofactor, 2,4,5-trihydroxyphenylalanine quinone (TPQ). Following the formation of aldehyde, the enz...
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Nine low-Mr thiols were compared with regard to their ability to function as myeloperoxidase-oxidase substrates under conditions where no auto-oxidation of the thiols could be observed. The methyl and ethyl esters of cysteine were found to be about twice as active as cysteamine at pH 7.0, in terms of increased O2 consumption. Cysteine itself was poorly active, whereas glutathione, N-acetylcyste...
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ژورنال
عنوان ژورنال: Plant and Cell Physiology
سال: 2014
ISSN: 1471-9053,0032-0781
DOI: 10.1093/pcp/pcu155